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Journal of Emerging Trends in Engineering and Applied Sciences (JETEAS)


Article Title: Preparation of Nanomaterials for Drug Delivery System via Microemulsion Polymerisation Method
by C.R. Laili and S. Hamdan

Microemulsion polymerisation method was employed in an initial attempt to prepare poly (alkylcyanoacrylate) nanomaterials. In this work,a region of water-in-oil microemulsion stabilised by non-ionic surfactant was identified and used as a templatefor the preparation of poly (alkylcyanoacrylate) nanomaterial. The non-ionic surfactants used were polyoxyetehylene (20) sorbitan monooleate (Tween 80) and Sorbitan monolaurate (Span 20). Monomers were added into the microemulsion template in order to obtain nanomaterial. The key physical properties of the materials were characterized employing standard techniques such as HPLC, FTIR, DLS, SEM and the in vitro release of insulin by dissolution method.Results from the FTIR showed that the poly (alkylcyanoacrylate) nanomaterials were successfully prepared and that the polymerisation of poly (alkylcyanoacrylate) nanomaterial was completed. The morphologies observed using SEM showed a porous honeycomb structure indicative of a bicontinuous type microemulsion. The size of the microemulsion template were found to be more than 300 nm which in turn resulted in the production of nanomaterials with particle size of more than 140 nm. Finally, from the dissolution studies, the nanomaterials was able to entrap a good amount of insulin but were unstable at the pH studied which mimic the gastrointestinal (GI) tract condition.
Keywords: microemulsion; nanomaterials, polymerisation; drug delivery; insulin
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ISSN: 2141-7016

Editor in Chief.

Prof. Gui Yun Tian
Professor of Sensor Technologies
School of Electrical, Electronic and Computer Engineering
University of Newcastle
United Kingdom



Copyright © Journal of Emerging Trends in Engineering and Applied Sciences 2010