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Journal of Emerging Trends in Engineering and Applied Sciences (JETEAS)

ISSN:2141-7016

Article Title: Biochemical Implications of the Consumption of Water from Otamiri River, Owerri, Imo State, Nigeria
by Akubugwo, E. I and Duru, M. K.C.

Abstract:
Biochemical studies on Otamiri river Owerri were carried out using albino rats. The results obtained for weight studies, showed that average weight change and average percentage weight change after administration of water and feed reduced significantly (p<0.05) in test rats when compared to those of the control rats. Liver function studies revealed a significant increase (p<0.05) in AST (8.43 +- 1.46 U/L), ALT (34.29 +- 3.61 U/L), and ALP (59.20 +- 1.87 iu/L) in the test rats against AST (2.23 +- 0.18 U/L), ALT (27.45 +- 2.47 U/L), and ALP (40.63 +- 4.44 iu/L) of the control. Total bilirubin and conjugated bilirubin in test rats increased insignificantly (p>0.05) against those of the control rats. Hematological studies showed a significant increase (p<0.05) in packed cell volume (49.10 +- 1.19%), hemoglobin (23.59 +- 1.19 g/dl), White blood cell total (5193.00 +- 277.37 cells/mm2), lymphocytes count (46.54 +- 1.72%), basophils count (19.90 +- 1.40%), and monocytes count (10.82 +- 0.63%) in test rats against packed cell volume (39.70 +- 1.21%), hemoglobin (17.07 +- 1.55 g/dl), White blood cell total (4005.00 +- 1.21 cells/mm2), lymphocytes count (40.65 +- 0.63%), basophils count (13.35 +- 1.54%) and monocytes count (3.31 +- 0.48%) of the control rats while neutrophils count (10.25 +- 1.92%), eosinophils count (3.43 +- 0.67%) and erythrocyte sedimentation rate (4.16 +- 0.66mm/hr), reduced significantly (p<0.05) in test rats when compared to neutrophils count (20.63 +- 0.96%), eosinophils count (21.10 +- 1.34%) and erythrocyte sedimentation rate (8.09 +- 0.75 mm/hr), of the control. The kidney function studies revealed that apart from creatinine, which reduced insignificantly (p>0.05) in test rats against the control, urea (19.47 +- 0.09 mg/dl), potassium ion (2.90 +- 0.04 mEq/L), sodium ion (43.06 +- 0.02mEq/L), chloride (80.40 +- 0.06 mEq/L), and bicarbonate (32.00 +- 0.02 mEq/L), reduced significantly (p<0.05) in test rats against urea (21.82 +- 0.07 mg/dl), potassium ion (3.70 +- 0.06 mEq/L), sodium ion (57.02 +- 0.03 mE/L), chloride (102.00 +- 0.04 mEq/L) and bicarbonate (36.20 +- 0.05 mEq/L) of the control rats. The prepresent study has shown that Otamiri river water has effects on biochemical parameters and people dependant on the river water especially for domestic uses may be exposed to these effects
Keywords: otamiri river, aldosterone, hematological studies, liver enzymes
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ISSN: 2141-7016

Editor in Chief.

Prof. Gui Yun Tian
Professor of Sensor Technologies
School of Electrical, Electronic and Computer Engineering
University of Newcastle
United Kingdom

 

 

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