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Journal of Emerging Trends in Engineering and Applied Sciences (JETEAS)

ISSN:2141-7016

Article Title: EFFECT OF METHANOLIC EXTRACT OF CARALLUMA LONGIDENS ON SOME CLINICAL PATHOGENS
by A.S. Barau

Abstract:
The whole part of the plant Caralluma longidens (family of Asclepiadaceae) was collected from Samaru, Zaria Kaduna State of Nigeria and is one of the plants that is frequently used among herbalist in some parts of Nigeria in the treatment of chest, stomach, lesion and urinary tract infections due these the plant extract was used to ascertain or otherwise this ethno medicinal claims. The whole part of the plant was extracted by continuous extraction using methanol solvent after defatting. The phytochemical screening of this plant showed the presence of steroids/terpenoids, flavonoids, carbohydrates, glycosides, cardiac glycoside, reducing sugar, tannins (hydrolysable) and saponins. The disc diffusion assay was performed to evaluate antimicrobial activity of the extract. The crude methanol extract was found to be sensitive on Staphylococcus aereus, Salmonella typhi, Klebsiella pneumonae, Candida albicans and Candida krusei showing significant zones of inhibition ranging from 21-32 mm, against the stated organisms. The minimum inhibitory concentrations (MIC) of methanol extract against the stated organisms were 2.5 mg/ml, 5 mg/ml 2.5 mg/ml, 5 mg/ml and 5 mg/ml respectively. Minimum bactericidal/fungicidal concentrations of the extract against S. aereus, S. typhi, K. pneumonae, C. albicans and C. krusei were found to be 10 mg/ml, 10 mg/ml, 10 mg/ml, 20 mg/ml and 20 mg/ml respectively. The plant was found to contained bioactive compounds that inhibit/kill some pathogens and it could be the sustainable source for new drug.
Keywords: caralluma longidens, asclepiadacea, phytochemical screening, antimicrobial studies, samaru.
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ISSN: 2141-7016

Editor in Chief.

Prof. Gui Yun Tian
Professor of Sensor Technologies
School of Electrical, Electronic and Computer Engineering
University of Newcastle
United Kingdom

 

 

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